===== Scrap =====

 

 

=== Activated protein C ===

[Jonathan's presentation]

Binds to platelet (Protein S potentiates action)

Inactivates  activated factor 5 and 8

Promotes frinolysis --> Helps with blood flow

Also anti-inflammatory actions

 

Used in critical patients

Expensive

5 and 20mg ampules

Infusion 48-96 hours

 

 

I

Life-threatening sepsis

Multiorgan failure

 

Precaution

Bleeding

Allergy

 

 

=== Platelet ===

Chris Breen

 

Platelet plug formation

C - Contact

A - Activation

S - Shape change (change to spherical)

S - Spread

R - Release of granules

A - Aggregation

 

=== antiplatelet ==

Jackie

 

Aspirin

Anti-ADP

Anti glycoprotein IIb/IIIa

Phosphodiesterase inhibitors

Misc
* Prostacyclin
* NO
* Dextran 40 and dextran 70

 

Side effects of cox inhibitors (RPG chaps)

R - renal

P - plaetlet

G - gastric

C - CNS irritability

H - hepatic

A - asthma

P - pregnancy (patent ductus arteriosus)

S - skin sensitisation

 

=== coagulation ===

BJ

 

 

initiation

amplification

prop

 

 

=== others ===

 

prothrombinex

Factors 2, 9, 10

(Not Factor 7, which is why it is expensive)

 

 

=== Activated factor 7 (NovoSeven) ===

New drug

Used in haemophilia, severe haemorrhage (use after massive transfusion, and FFP, and still bleeding)

Does not have systemic effect (goes straight to the area where the bleeding is)

SE include

Fever, headache, pain,

Thrombosis, PE, AFR, stroke, anaphylaxis