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Notes
      3. Old stuff
          3.1. Old pharm stuff (pre 2009)
              3.1.3. Pharmacology
                  3.1.3.5. Opioids
                      3.1.3.5.3. Opioid agonists
 3.1.3.5.3.10. Opioid dose conversion 

Opioid dose conversion

[MR2:p19]

Equianalgesic doses
Opioid IM/IV (mg) Oral (mg) T1/2 (hours)
Morphine 10 30 2-3
Pethidine 100 400 3-4
Oxycodone 15 20-30 2-3
Codeine 130 200 2-4
Fentanyl 0.150 - 0.200 3-5
Alfentanil 0.750 - 1.500 1-2
Sufentanil 0.020 2-3
Tramadol 100 100 5-7
Diamorphine 5 60 0.5
Methadone 10 10-15 15-40
Hydromorphone 1.5 7.5 3-4
Buprenorphine 0.4 0.8 (S/L) 3-5
Pentazocine 60 150 3-5
Nalbuphine 10-20 2-4
Butorphanol 2 2-3

 

NB:

[CJA 2005(52(5)):p513-523]

  • Opioid dose conversions are based on single-dosing trials
  • Conversions are NOT bi-directional
  • Cross-tolerance are often incomplete and unpredictable
  • There is NO universally accepted conversion ratio

 

Bibliography
Methadone and acute pain (Peng)
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Table of contents  | Bibliography  | Index
Revised at 2007/10/25 22:53