Previous page 3.1.3.1.2.3.2. Altered drug response   75 / 795  Next page 3.1.3.1.3.1. Porphyria Return 3.1.3.1. Pharmacology principles
Notes
      3. Old stuff
          3.1. Old pharm stuff (pre 2009)
              3.1.3. Pharmacology
                  3.1.3.1. Pharmacology principles
 3.1.3.1.3. Pharmacogenetics 
 1. Porphyria
 2. Atypical plasma cholinesterase
 3. Malignant hyperthermia

Pharmacogenetics

[Prof Kam's lecture notes]

Potential consequences of polymorphic drug metabolism

  • Extended pharamcological effect
  • Adverse drug reaction
  • Lack of prodrug activation
  • Increased effective dose
  • Metabolisim by alternative deleterious pathways
  • Drug interaction

Anaesthetic drug related

  • Porphyria
  • Plasma cholinesterase deficiency
  • Malignant hyperthermia

Other drug

  • G-6-P dehydrogenase deficiency
  • Alcohol dehydrogenase deficiency
  • N-Acetyl transferase
  • Glucuronyl transferase
  • Debrisoquine /sparteine hydroxylase (CYP2D6)

 

 

 

Previous page 3.1.3.1.2.3.2. Altered drug response Next page 3.1.3.1.3.1. Porphyria Return 3.1.3.1. Pharmacology principles
Table of contents  | Bibliography  | Index
Revised at 2007/02/02 00:19