Things to note about hormones

Using insulin as example:

hormone structure

receptor structure

 

production (where)

halflife

metabolism/elimination/excretion

 

effect of action

 

factors affecting secretion/excretion

regulation of secretion/excretion

 

 

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Still need to do

glucocorticoids

 

 

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Permissive actions of glucocorticoids

Allows glucagon and catecholamines to exert their calorigenic effect

For catecholamines to exert their lipolytic effect

For catecholamines to produce pressor response and bronchodilation

 

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Histamine

[WG21:p108, p600, p497]

Histamine is formed by decarboxylation of histidine

Found in

• Gastric mucosal cells
• Mast cells
• Some CNS neurons
  * Tuberomammilary nucleus of the posterior hypothalamus

Receptors

3 types: H1, H2, H3

H1

Activates phospholipase C

• Vasoconstriction [WG21:p600]
• Pulmonary vasodilation [WG21:p666]
• Smooth muscle contraction in ileum, bronchioles, and uterus [RD5:p230]

H2

Increases cAMP

• Vasodilation [WG21:p600]
• Pulmonary vasodilation [WG21:p666]
• Gastric acid secretion [WG21:p497]
• Tachycardia [RD5:p230]
• Increased cardiac contractility [RD5:p230]