Non-respiratory function of lung

[KB2:p142]

• Blood reservoir
• Blood filtration
• Metabolic
  * Surfactant
  * Protein synthesis
  * Removal of proteases (alpha-1 antitrypsin)
  * Carbohydrate metabolism
  * Metabolism of vasoactive substances
• Immunological/protective function
  * Alveolar macrophages
  * IgA
• Heat regulation
• Facilitate speech
• Drug administration/elimination

Vasoactive compounds

[KB2:p143]

• Angiotensin I is converted to angiotensin II
• Bradykinin is inactivated
• Serotinin is taken up

Lung removes and releases...

[WG22:p665]

Lung partially removes from blood

• Prostaglandins
• Serotonin
• NE
• Ach
• Bradykinin
• Adenine nucleotides

Lung releases into blood

• Prostaglandins
• Histamine
• Kallikrein