3. Old stuff
          3.2. Old physio stuff (around 2005)
 3.2.1. Pharmacology 

Topics

Today's topic

Chp 21 Histamine

Chp 24 Insulin

Chp 25 Diuretics

Chp 27 Anticoagulants

Chp 28 Antimicrobials

Chp 32 Lipid disorder

Chp 33 CNS stimulants and muscle relaxants

Chp 36 Bloods

 

The BIG FIVE

  1. Inhaled anaesthetics
  2. Intravenous anaesthetics
    * Barbiturates
    * Benzodiazepines
    * Nonbarbiturate IV anaesthetics
  3. Local anaesthetics
  4. Analgesia
    * Opioids
    * NSAIDs
  5. Muscle-relaxants
    * Also reversals (anticholinesterase)

Other important topics

CVS drugs
* Sympathomimetics
* Digitalis and others
* Adrenoreceptor antagonists
* Antihypertensive drugs
* Anti-arrhythmics
* Vasodilators

Antiemetics

Diuretics

Anti-microbials

Drugs affecting coagulation

Hypoglycaemic agents

 

 

Corticosteroids and other hormone preparations

Drugs acting on the GIT

CNS drugs

 

Phase I vs Phase II block

 

 

Topics skipped (needs to go back to)

Chp 19 Psych drugs

Chp 20 Prostaglandins

Chp 22 Serotonin

Chp 23 Hormones

Chp 26  Antacids and GIT drugs

Chp 29 Chemotherapeutic

Chp 30 Antiepileptic drugs

Chp 31 Parkinson's drug

Chp 34 Vitamins

Chp 35 Minerals and electrolytes

Chp 37 Enteral and parenteral nutrition

Chp 38 Antiseptics and disinfectants

 

Topics to make flash cards on

Droperidol

Haloperidol

Clonidine

Inhaled anaesthetics

  1. ISO
  2. SEVO
  3. DES
  4. HAL
  5. ENF
  6. METH
  7. N2O

Intravenous anaesthetics

Barbiturates

  1. Thiopentone
  2. ??? Methohexital
  3. ??? Phenobarbital
  4. ???

Benzodiazepines

  1. Midazolam
  2. Diazepam
  3. Flumazenil

Non-barbiturate IV anaesthetic drugs

  1. Propofol
  2. Ketamine
  3. Etomidate

Local anaesthetics

Ester

 

Amide

 

Analgesia

Opioid

  1. Morphine
  2. Fentanyl
  3. Sufentanil
  4. Alfentanil
  5. Remifentanil
  6. Methadone 
  7. Tramadol
  8. Codeine
  9. Pethidine
  10. Naloxone
  11. Heroin

 

 

 

Muscle-relaxants

 

Adrenoreceptor antagonists
  1. Propanolol
  2. Esmolol
  3. Metoprolol
  4. Atenolol
  5. Timolol
  6. Labetalol
  7. Prazosin
  8. Clonidine
  9. Dexmedetomidine

 

Drug information to note

For every drug, I need to know

 

Classification

Pharmaceutical information

Formulation/preparation

Price

pH of preparation

Preservatives

Solvent

Administration/Route

Dosage

pK

Pharmacodynamics

Mechanism of action
* e.g. receptors of action

Receptor and cellular level

Organ system (CVS, CNS, Resp, GIT, genitourinary, maternal/foetal, uterus, cutaneous, placenta

Pharmacokinetics

  • Absorption
    * Route of administration
    * Speed
    * Bioavailability
  • Distribution
    * Onset of action
    * Effect-site equilibration time
    * Redistribution
    * Vd
    * Protein-binding
  • Metabolism
    * Hepatic and extrahepatic metabolism
    * Metabolite, active/inactive
    *
  • Excretion
    * Duration of action
    * Half-time (context-sensitive, elimination)
    * Clearance (hepatic and renal)
    * Impact of cirrhosis and renal failure

 

Clinical information

  • Dosage
  • Special notes

Adverse effects

  • Side-effect
  • Drug interaction