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Notes
      3. Old stuff
          3.2. Old physio stuff (around 2005)
              3.2.3. Physiology
                  3.2.3.1. Acid and base
                      3.2.3.1.2. Defence to acid-base disturbance
                          3.2.3.1.2.1. Buffer
 3.2.3.1.2.1.2. pKa 

pKa

PO4

pKa for PO4

--> 2, 6.8, 12

Because intracellular pH is lower (6.8-7.1)
--> Phosphate more effective intracellularly (in addition to greater concentration)

Intracellular phosphate = 60 mmol/L

 

Hb

pKa for DeoxyHb = 8.2

pKa for OxyHb = 6.6

But average pKa for Hb = 6.8 [BK2:p25]

NB:

  • Should be the same for protein since it's the same imidazole group in histidine that provides buffering
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