3. Old stuff
          3.1. Old pharm stuff (pre 2009)
              3.1.4. Physiology
                  3.1.4.4. Haematology
                      3.1.4.4.1. Haemostasis
                          3.1.4.4.1.1. Clot formation
 3.1.4.4.1.1.2. Coagulation cascade 

A.1.3. Coagulation cascade

  • Conversion of plug into definitive clot is by formation of insoluble fibrin from soluble plasma protein fibrinogen
  • Fibrin initially is a loose mesh of interlacing strands
  • Stabilisation is when this loose mesh is converted to a tight and dense aggregate via formation of covalent cross-linkages