Metaraminol

[PHW2:p203]

Synthetic amine

Pharmacodynamics

Mechanism of action

[PHW2:p203]

Both direct and indirect sympathomimetic actions

Mainly alpha1 activity

Some beta activity

Effects

[PHW2:p203]

CVS

Increased SVR
--> Increased BP

Decreased CO
* Despite some activity at beta receptors

Coronary perfusion increased (via an indirect mechanism)
* ???

Pulmonary vascular resistance increased

Uterine artery blood flow decreased
* Similar to methoxamine
* Not used to correct hypotension associated with regional anaesthesia in obstetrics

Pharmacokinetics

Pharmaceutics

Clinical