Pharmacodynamics

03B3, 01A10
Outline GABA's role as a neurotransmitter and indicate how its actions may be modified by pharmacological agents.
63%

01A9
Briefly describe how drugs produce their pharmacological effects. Illustrate each mechanism with examples.
75%

00B11
Describe the structure and function of G proteins
50%

1999
Using opioids as examples describe and illustrate with graphs what you understand by the terms 'potency', 'efficacy', 'partial agonist', 'competitive antagonist' and 'therapeutic index'.
77%

97A9
Briefly describe the pharmacological role of the nicotinic cholinergic receptor
62%

1997
What do you understand by the term 'clearance'? Using propofol as an example, explain briefly the importance of clearance

1997
Briefly describe the drug factors that may predispose to thrombophlebitis

96B12
Briefly describe how drugs may produce their pharmacological effects. Illustrate each mechanism with examples.
30%

96A16
Define therapeutic index and briefly outline its significance. Describe briefly also the therapeutic ratio and the use of the of the cardiac/cns toxicity ratio (cns = central nervous system)
79%

1994
Briefly explain non-competitive antagonism at receptor sites and give two examples

1994
Briefly describe the possible mechanism of action of general anaesthetics

1993
Briefly outline the chemistry of soda lime and the potential interactions with anaesthetic agents

93A2
Define potency, affinity and efficacy illustrating your answer by reference to opioids in clinical use [See also 95B9]
84%

1991
Write short notes on log dose effect curves