Pharmacokinetics

2006B03

Describe the factors which contribute to the inter-individual variability in drug response seen with intravenous anaestethetic induction agents. 39%

 

 

 

02B1
Outline the influences of pregnancy on pharmacokinetics
39%

 

02B2
Briefly describe the factors affecting the uptake of orally administered medicines
67%

 

02A10 (also in 99B16, 98A13)
Outline the factors that determine recovery (offset of action) after ceasing a drug infusion.
43%

 

01A11
Define the term 'context-sensitive half time'. How does this differ from the elimination half life? Illustrate your answer by comparing thiopentone vs. propofol, and fentanyl vs. remifentanil
64%

 

00A14
Discuss the roles of the plasma esterases on drugs used in anaesthesia
67%

 

96A13
Describe briefly the factors determining transdermal uptake of drugs and give some examples of drugs that can be administered by the transdermal route.
Briefly outline the advantages and disadvantages of transdermal administration of drugs.
79%

 

1995
Describe the clearance of drugs by the kidney

 

1995B3
Give a brief account of drug protein binding and outline its significance

 

95B8
Outline the factors that determine recovery (offset of effect) after ceasing a drug infusion.
Explain the relevance of a drug’s elimination half time.
6%

 

95A3
Define Phase I and Phase II reactions in drug metabolism. Provide examples with drugs used in anaesthesia.
70%

 

95A2
Define a 'steady state' in pharmacology. List the advantages and disadvantages of a steady state and outline the characteristics of drugs which make them suitable for steady state pharmacology
65%

 

95A4
Briefly describe the factors affecting the uptake of orally administered medicines
76%

 

1994
Discuss the ways in which the consequences of liver disease may influence drug disposition.

 

1992
Write short notes on binding of drugs to plasma proteins

 

1992
Write short notes on measurement of whole body drug clearance

 

1992
Write short notes on zero order kinetics

 

1992
Write short notes on Hepatic extraction ratios

 

1991
Write short notes on the clearance of drugs

 

1991
Write short notes on estimation of apparent volume of distribution of a drug

 

1991
Write short notes on binding of drugs to plasma proteins

 

1990
Define bio-availability. Discuss the factors which determine the bio-availability of a drug.