Muscle Relaxants & Antagonists

03A8
Describe the onset and offset of neuromuscular block at the diaphragm, larynx and adductor pollicis after administration of 2.5 x ED95 dose of vecuronium. Comment on the differences observed. What are the clinical implications of these differences?
50%

 

02B5
Outline the possible reasons for prolongation of paralysis induced by an intravenous dose of 1 mg.kg-1 of suxamethonium. Briefly indicate the consequences of such a prolonged block.
60%

 

01B13
Compare and contrast neostigmine and the organophosphorus compounds.
64%

 

01A14
Give examples of drugs that enhance the action of the non-depolarising neuromuscular blocking agents at the neuromuscular junction. Briefly describe the mechanisms of these interactions.

 

00B16
Compare and contrast the pharmacology of atracurium and cis-atracurium
26%

 

99B10
Outline factors determining speed of onset of neuromuscular blocking agents
58%

 

99A12
Explain the phenomena known as fade and post tetanic facilitation associated with the use of neuromuscular blocking agents.
43%

 

98B13
Draw and explain the characteristics of a log  dose-response curve that describes the major clinical effect of vecuronium. List factors encountered in clinical practice that may alter this curve
46%

 

98A15
Compare the metabolism of suxamethonium to that of atracurium.
83%

 

1997
Briefly describe the pharmacological actions of the anti-cholinesterases with reference to edrophonium, neostigmine and the organophosphorus compounds. Indicate the similarities and differences with the 3 drugs

 

1997
Give examples of drugs that enhance the action of the non-depolarising neuromuscular blocking agents at the neuromuscular junction. Briefly describe the mechanisms of their actions.
41%

 

96B16
Outline briefly the possible reasons for prolongation of paralysis induced by an intravenous dose of 1mg/kg of suxamethonium. Briefly indicate the consequences of such a prolonged block.
58%

 

1994
Explain the use of the peripheral nerve stimulator in monitoring muscle relaxants and their offset.

 

1993
What factors may alter plasma cholinesterase activity and how can this activity be measured

 

1993
Briefly discuss the side effects of atracurium

 

1992
Write short notes on atracurium

 

1990
Write short notes on post tetanic facilitation

 

1990
Write short notes on dibucaine number