Previous page 3.2.3.12.7.4.3. Antidiuretic hormone (aka Vasopressin)   504 / 795  Next page 3.2.3.12.8. Renal regulation of potassium Return 3.2.3.12.7.4. Control of Sodium balance
Notes
      3. Old stuff
          3.2. Old physio stuff (around 2005)
              3.2.3. Physiology
                  3.2.3.12. Renal
                      3.2.3.12.7. Control of sodium and water excretion
                          3.2.3.12.7.4. Control of Sodium balance
 3.2.3.12.7.4.4. Renal nerve stimulation 

Renal nerve stimulation

[Ref: AV6:p121]

Effect of renal nerve stimulation

  1. Stimulates renin secretion via direct action on beta1-receptors on JG cells
  2. Stimulates sodium reabsorption via a direct action on tubular cells
    * Including proximal tubular cells, ascending limb, and distal tubules
    * [WG21:p707]
  3. Stimulates afferent and efferent arteriolar constriction (alpha-adrenergic receptors)

Thus,

  • GFR decreases
  • RBF decrease even more

Which leads to

  • Decreased hydrostatic pressure in peritubular capillaries, AND
  • Increased filtration fraction increases oncotic pressure in peritubular capillaries

Thus,

  • Sodium reabsorption increases, mainly in proximal tubule
  • Decreased GFR and increased proximal sodium resorption further leads to increase in renin
    * By decreasing NaCl content at macula densa

NB:

The 3 effects of renal nerve are listed in the order of nerve impulse required

Thus,

  • Renin secretion is triggered first at lower levels of renal nerve activity
  • Afferent and efferent arteriolar constriction occur last

 

Previous page 3.2.3.12.7.4.3. Antidiuretic hormone (aka Vasopressin) Next page 3.2.3.12.8. Renal regulation of potassium Return 3.2.3.12.7.4. Control of Sodium balance
Table of contents  | Bibliography  | Index
Revised at 2012/10/25 14:03