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Notes
      3. Old stuff
          3.2. Old physio stuff (around 2005)
              3.2.1. Pharmacology
                  3.2.1.6. Antiemetic
                      3.2.1.6.1. Dopamine antagonist
 3.2.1.6.1.2. Butyrophenones 

Butyrophenone

Droperidol

Effective at doses from 0.25mg to 0.5mg

Ceiling effect at 2.5mg
* [Brisbane May 2005 course]

Sedation more pronounced than phenothiazines

CVS adverse effects

  • QT prolongation
  • Torsade de pointes
  • Cardiac arrest
  • Ventricular tachycardia

Other side-effects

  • Hyperprolactinaemia
  • Hypotension
    * Due to alpha1-antagonism
  • Extrapyramidal effects
  • Dysphoria (dose-related)
  • Blackboxed in US due to possible link to sudden cardiac death
  • Anti-nausea effect is greater than anti-emetic effect
    * [Brisbane May 2005 course]

 

 

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