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Notes
      3. Old stuff
          3.2. Old physio stuff (around 2005)
              3.2.1. Pharmacology
                  3.2.1.6. Antiemetic
 3.2.1.6.2. 5-HT3 antagonist 

5-HT3 antagonist

Few comparisons done within classes
--> Selection is mostly based on cost and availability

Ineffective for N&V induced by motion sickness or dopamine agonist

 

Ondansetron

  • Well absorbed from GIT (bioavailability of 60%)
  • Significant hepatic metabolism
    --> Reduce dose in hepatic impairment
  • Half-life = 3 hours

Side-effect

  • Headache (15-20%)
  • Flushing
  • Constipation
  • Bradycardia

Usage

  • Cytotoxic chemotherapy-induced N&V
  • PONV
  • Radiation-induced N&V
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