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Notes
      3. Old stuff
          3.2. Old physio stuff (around 2005)
              3.2.3. Physiology
                  3.2.3.2. Cardiovascular
                      3.2.3.2.4. Regulatory mechanisms
                          3.2.3.2.4.3. Control of cardiac output
 3.2.3.2.4.3.1. Cardiac function curve (of Guyton) 

Cardiac function curve (of Guyton)

  • An expression of Frank-Starling curve
    * But NOT the actual Frank-Starling curve
    * Original Frank-Starling curve shows relationship between preload and stroke volume, and is not affected by afterload.
  • Dependent on characteristics of the heart
  • Shows effects of increases in right atrial pressure (independent variable) on the cardiac output (dependent variable).
  • Due to heterometric autoregulation (i.e. autoregulation that is related to length of fibre)
    * cf. homometric autoregulation - independent of fibre length

Shifts in the cardiac function curve

Increased contractility

--> Cardiac function curve moves up

Increased peripheral resistance

--> Cardiac function curve moves down

 

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